Iwasaki Y, Shiojima T, Tagaya N, Kobayashi T, Kinoshita M
Fourth Department of Internal Medicine, Toho University, Ohashi Hospital, Tokyo, Japan.
Neurol Res. 1997 Oct;19(5):555-7. doi: 10.1080/01616412.1997.11740857.
In vivo, motor neurons are destined to die after axotomy. Several neuronal growth factors, such as ciliary neurotrophic factor, brain-derived neurotrophic factor, and leukemia inhibitory factor rescue neuronal death of axotomized motor neurons. Here, we report that systemically administered basic fibroblast growth factor and platelet-derived growth factor prevented spinal motor neuron death in neonatal rats following sciatic nerve resection. These data indicate that basic fibroblast growth factor and platelet derived growth factor play a role for motor neuron survival in vivo.
在体内，运动神经元在轴突切断后注定会死亡。几种神经元生长因子，如睫状神经营养因子、脑源性神经营养因子和白血病抑制因子，可挽救轴突切断的运动神经元的死亡。在此，我们报告，全身给予碱性成纤维细胞生长因子和血小板衍生生长因子可预防新生大鼠坐骨神经切除后脊髓运动神经元的死亡。这些数据表明碱性成纤维细胞生长因子和血小板衍生生长因子在体内对运动神经元的存活起作用。
