促甲状腺激素释放激素类似物TA-0910（3-甲基-（s）-5,6-二氢乳清酸-L-组氨酰-L-脯氨酰胺）可挽救轴突切断诱导的运动神经元细胞死亡。

TRH-analog, TA-0910 (3-methyl-(s)-5,6-dihydroorotyl-L-histidyl-L-prolinamide) rescues motor neurons from axotomy-induced cell death.

作者信息

Iwasaki Y, Shiojima T, Tagaya N, Kobayashi T, Kinoshita M

机构信息

Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.

出版信息

Neurol Res. 1997 Dec;19(6):613-6. doi: 10.1080/01616412.1997.11740869.

DOI:10.1080/01616412.1997.11740869

PMID:9427962

Abstract

TA-0910 (3-methyl-(s)-5,6-dihydroorotyl-L-histidyl-L-prolinamide) is a potent and long acting TRH analog. We have studied the effect of TA-0910 on axotomy-induced neuronal death. The left sciatic nerve was transected in neonatal rats. TA-0910 or vehicle was administered on consecutive 14 days with intraperitoneal injections. After the treatment, the number of spinal motor neurons and the motor neuron diameter was assessed at the level of L4-6 segments. In comparison with vehicle, TA-0910 significantly prevented the death of motor neurons and preserved the motor neuron diameter on the lesioned side. These results suggest that TA-0910 is a survival factor for developing spinal motor neurons.

摘要

TA - 0910（3 - 甲基 -（S）- 5,6 - 二氢乳清酸基 - L - 组氨酰 - L - 脯氨酰胺）是一种强效且长效的促甲状腺激素释放激素（TRH）类似物。我们研究了TA - 0910对轴突切断诱导的神经元死亡的影响。在新生大鼠中切断左侧坐骨神经。连续14天腹腔注射TA - 0910或赋形剂。治疗后，在L4 - 6节段水平评估脊髓运动神经元的数量和运动神经元直径。与赋形剂相比，TA - 0910显著预防了运动神经元的死亡，并保留了损伤侧的运动神经元直径。这些结果表明，TA - 0910是发育中的脊髓运动神经元的存活因子。