衰老生物学何时会变得有用？生物医学老年学的未来里程碑。

When will the biology of aging become useful? Future landmarks in biomedical gerontology.

作者信息

Miller R A

机构信息

Department of Pathology, University of Michigan, Ann Arbor 48109-0642, USA.

出版信息

J Am Geriatr Soc. 1997 Oct;45(10):1258-67. doi: 10.1111/j.1532-5415.1997.tb03781.x.

DOI:10.1111/j.1532-5415.1997.tb03781.x

PMID:9329491

Abstract

Where should we look to find the causes of and cure for aging? This essay considers a number of scientific discoveries, not yet made, that might dramatically increase the proportion of biogerontologists doing useful work. I will consider, in turn, problems and prospects in the areas of comparative biology, mammalian and invertebrate genetics, biomarker research, caloric restriction, and clonal senescence and then conclude with a discussion of potential links between aging and late life disease.

摘要

我们应该从何处探寻衰老的成因及治愈方法呢？本文探讨了一些尚未取得的科学发现，这些发现可能会大幅提高从事有用工作的生物老年医学家的比例。我将依次探讨比较生物学、哺乳动物和无脊椎动物遗传学、生物标志物研究、热量限制以及克隆衰老等领域的问题与前景，最后讨论衰老与晚年疾病之间的潜在联系。