Friedrich R E, Bartel-Friedrich S, Plambeck K, Bahlo M, Klapdor R
Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany.
Anticancer Res. 1997 Jul-Aug;17(4B):3183-4.
To investigate the sera of patients with oral squamous cell carcinoma (OSCC) for the existence of p53 auto-antibodies.
The sera of thirty-nine OSCC-patients were investigated. All samples were from untreated patients with no history of another neoplastic disease. The sera of nine healthy subjects served as controls.
P53 auto-antibodies were not detected both in all healthy subjects and in 20.6% OSCC-patients with their disease at an advanced stage. We prove that the extinction rates for p53 auto-antibodies in OSCC are very weak in the majority of investigated sera (50%) and are not related to tumour stage.
It is unlikely that p53 auto-antibodies can serve as a prognostic marker of OSCC.
研究口腔鳞状细胞癌（OSCC）患者血清中是否存在p53自身抗体。
对39例OSCC患者的血清进行了研究。所有样本均来自未接受治疗且无其他肿瘤疾病史的患者。9名健康受试者的血清作为对照。
在所有健康受试者以及20.6%处于疾病晚期的OSCC患者中均未检测到p53自身抗体。我们证实，在大多数被调查血清（50%）中，OSCC患者血清中p53自身抗体的消亡率非常低，且与肿瘤分期无关。
p53自身抗体不太可能作为OSCC的预后标志物。
