Kondo N, Fukutomi O, Shinbara M, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
Biotherapy. 1994;8(1):19-22. doi: 10.1007/BF01878117.
N(3',4'-dimethoxycinnamoyl) anthranilic acid (Tranilast) inhibits antibody-mediated hypersensitivity reactions, and is an effective drug for patients with bronchial asthma or allergic rhinitis. Interferon-gamma (IFN-gamma) production of ovalbumin (OA)-stimulated peripheral blood mononuclear cells (PBMCs) from hen's egg-sensitive patients with atopic dermatitis (AD) was significantly higher than those of healthy controls. Tranilast inhibited this IFN-gamma production. Moreover, interleukin-2 (IL-2) production of OA-stimulated PBMCs from hen's egg-sensitive patients with AD was also inhibited by Tranilast. Our results suggest that Tranilast can be used to the patients with food sensitive AD.
N-(3',4'-二甲氧基肉桂酰)邻氨基苯甲酸（曲尼司特）可抑制抗体介导的超敏反应，是治疗支气管哮喘或过敏性鼻炎患者的有效药物。来自鸡蛋敏感的特应性皮炎（AD）患者的卵清蛋白（OA）刺激的外周血单个核细胞（PBMC）产生的干扰素-γ（IFN-γ）显著高于健康对照。曲尼司特抑制这种IFN-γ的产生。此外，曲尼司特还抑制来自鸡蛋敏感的AD患者的OA刺激的PBMC产生白细胞介素-2（IL-2）。我们的结果表明，曲尼司特可用于食物敏感的AD患者。
