Lenderking W R, Testa M A, Katzenstein D, Hammer S
Phase V Technologies, Inc., Wellesley, MA 02181, USA.
Qual Life Res. 1997 Aug;6(6):515-30. doi: 10.1023/a:1018408115729.
to examine the reliability and validity of the General Health Self-assessment, a modular questionnaire for self-assessment of quality of life (QoL) in human immunodeficiency virus (HIV) clinical trials and to describe the baseline QoL of participants in a large HIV clinical trial.
the domains assessed include health perceptions, physical, psychological and role/social functioning, health care utilization and symptom distress.
1,694 subjects with early HIV infection enrolled in the AIDS Clinical Trials Group Protocol 175 completed the scale at baseline.
the domains demonstrated reliability, construct and discriminant validity. A worse QoL was associated with recent hospitalization and symptomatic status. Prior antiretroviral therapy was associated with higher health perceptions and well-being. The presence of symptom distress was related to lower QoL on the other scales. There was no relationship between QoL scales and the baseline CD4 count. Women showed a lower QoL than men on all scales, while ethnicity was related to differences in health perceptions and physical and psychological functioning.
the General Health Self-assessment shows excellent potential as a measure of QoL for HIV-infected patients in clinical trials. Further research is necessary to determine the responsiveness of the scale to clinical and immunological changes in HIV-infected individuals.
检验《总体健康自我评估》的信度和效度，这是一份用于人类免疫缺陷病毒（HIV）临床试验中生活质量（QoL）自我评估的模块化问卷，并描述一项大型HIV临床试验中参与者的基线生活质量。
评估的领域包括健康认知、身体、心理和角色/社会功能、医疗保健利用及症状困扰。
1694名早期HIV感染受试者参与了艾滋病临床试验组方案175，并在基线时完成了该量表。
这些领域显示出信度、结构效度和区分效度。较差的生活质量与近期住院和症状状态相关。既往抗逆转录病毒治疗与更高的健康认知和幸福感相关。症状困扰的存在与其他量表上较低的生活质量相关。生活质量量表与基线CD4计数之间没有关系。在所有量表上，女性的生活质量均低于男性，而种族与健康认知以及身体和心理功能的差异有关。
《总体健康自我评估》作为临床试验中HIV感染患者生活质量的一项测量工具显示出巨大潜力。有必要进行进一步研究以确定该量表对HIV感染者临床和免疫变化的反应性。
