β亚基Kvβ1.2作为NH2末端缺失的Kv1.4α亚基的快速开放通道阻滞剂。
The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits.
作者信息
Rasmusson R L, Wang S, Castellino R C, Morales M J, Strauss H C
机构信息
Department of Biomedical Engineering, School of Engineering, Duke University, Durham, NC 27708, USA.
出版信息
Adv Exp Med Biol. 1997;430:29-37. doi: 10.1007/978-1-4615-5959-7_3.
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kv beta 1.2 has kinetic properties which are consistent with rapid open channel block.
最近发现的一类辅助亚基已被证明可改变属于钾通道Kv1家族的α亚基的失活特性。其中一个亚基Kvβ1.2可改变内在α亚基的C型失活。有人提出N型失活和开放通道阻断可增加C型失活的发展速率。我们在此证明，Kvβ1.2具有与快速开放通道阻断相一致的动力学特性。
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