心脏兴奋：离子通道与缝隙连接的相互作用过程。

Cardiac excitation: an interactive process of ion channels and gap junctions.

作者信息

Rudy Y, Shaw R M

机构信息

Cardiac Bioelectricity Research and Training Center (CBRTC), Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106-7207, USA.

出版信息

Adv Exp Med Biol. 1997;430:269-79. doi: 10.1007/978-1-4615-5959-7_23.

DOI:10.1007/978-1-4615-5959-7_23

PMID:9330736

Abstract

Theoretical simulations were performed to study the interplay between membrane ionic currents and gap-junction coupling in determining cardiac conduction. Results demonstrate that a much slower conduction velocity can be achieved with reduced gap-junction coupling than with reduced membrane excitability. Also, uniform reduction in intercellular coupling increases spatial asymmetries of excitability and, consequently, the vulnerability to unidirectional block.

摘要

进行了理论模拟，以研究膜离子电流和缝隙连接耦合在决定心脏传导方面的相互作用。结果表明，与降低膜兴奋性相比，降低缝隙连接耦合可实现更慢的传导速度。此外，细胞间耦合的均匀降低会增加兴奋性的空间不对称性，从而增加单向阻滞的易感性。