Rohr S, Kucera J P, Fast V G, Kléber A G
Department of Physiology, University of Bern, Bühlplatz 5, CH-3012 Bern, Switzerland.
Science. 1997 Feb 7;275(5301):841-4. doi: 10.1126/science.275.5301.841.
Generally, impulse propagation in cardiac tissue is assumed to be impaired by a reduction of intercellular electrical coupling or by the presence of structural discontinuities. Contrary to this notion, the spatially uniform reduction of electrical coupling induced successful conduction in discontinuous cardiac tissue structures exhibiting unidirectional conduction block. This seemingly paradoxical finding can be explained by a nonsymmetric effect of uncoupling on the current source and the current sink in the preparations used. It suggests that partial cellular uncoupling might prevent the initiation of cardiac arrhythmias that are dependent on the presence of unidirectional conduction block.
一般来说，心脏组织中的冲动传播被认为会因细胞间电耦合的减少或结构不连续性的存在而受损。与这一观点相反，在表现出单向传导阻滞的不连续心脏组织结构中，电耦合的空间均匀减少却能诱导成功传导。这一看似矛盾的发现可以通过去耦合对所用制剂中电流源和电流汇的非对称效应来解释。这表明部分细胞去耦合可能会预防依赖单向传导阻滞存在的心律失常的发生。
