Ch'en F, Clarke K, Vaughan-Jones R, Noble D
Balliol College, University of Oxford, UK.
Adv Exp Med Biol. 1997;430:281-90. doi: 10.1007/978-1-4615-5959-7_24.
Arrhythmias are caused by the interdependent processes of change in energy metabolism and alterations in sarcolemmal ion gradients that occur during ischemia. Depletion of energy metabolites and increased proton concentrations in ischemic heart may underlie the observed phenomena of reduced contractile force and also of malignant ventricular arrhythmias that can lead to tachycardia and ventricular fibrillation. Recent advances in measuring changes in ion concentrations and metabolites during cardiac ischemia have provided a wealth of detail on the processes involved. Some of the experimental data have been used to construct a computer model that integrates cardiac energetics with electrophysiological changes. This is a novel approach to studying myocardial ischemia, and the resulting model would aid in the prediction of the effects of therapeutic interventions.
心律失常是由缺血期间发生的能量代谢变化和肌膜离子梯度改变这两个相互依存的过程引起的。缺血心脏中能量代谢物的耗竭和质子浓度的增加可能是观察到的收缩力降低现象以及可能导致心动过速和心室颤动的恶性室性心律失常的基础。在测量心脏缺血期间离子浓度和代谢物变化方面的最新进展提供了有关所涉及过程的大量详细信息。一些实验数据已被用于构建一个将心脏能量学与电生理变化整合在一起的计算机模型。这是一种研究心肌缺血的新方法，由此产生的模型将有助于预测治疗干预的效果。
