Vaheri A, Carpén O, Heiska L, Helander T S, Jääskeläinen J, Majander-Nordenswan P, Sainio M, Timonen T, Turunen O
Haartman Institute, University of Helsinki, Finland.
Curr Opin Cell Biol. 1997 Oct;9(5):659-66. doi: 10.1016/s0955-0674(97)80119-6.
Ezrin, radixin, moesin and merlin form a subfamily of conserved proteins in the band 4.1 superfamily. Ezrin protein subfamily members act as linkers between the plasma membrane and the cytoskeleton. Members of the subfamily have been shown to interact with each other, with cell adhesion molecules such as CD44 and with F-actin. Recent data indicate that intercellular adhesion molecules 1 and 2 also interact with ezrin. The proteins are also involved in the redistribution of intercellular adhesion molecules and the organization of cell membrane structures. Merlin is a tumor suppressor that is involved in tumorigenesis of schwannomas and meningiomas. Merlin has the same overall protein structure as the other proteins in the subfamily but may have partially distinct functions.
埃兹蛋白、根蛋白、膜突蛋白和墨林蛋白在4.1带超家族中构成一个保守蛋白亚家族。埃兹蛋白亚家族成员充当质膜与细胞骨架之间的连接物。该亚家族成员已被证明可相互作用，与细胞粘附分子如CD44以及F-肌动蛋白相互作用。最新数据表明，细胞间粘附分子1和2也与埃兹蛋白相互作用。这些蛋白还参与细胞间粘附分子的重新分布以及细胞膜结构的组织。墨林蛋白是一种肿瘤抑制因子，参与神经鞘瘤和脑膜瘤的肿瘤发生。墨林蛋白与该亚家族中的其他蛋白具有相同的整体蛋白质结构，但可能具有部分不同的功能。
