钙黏着蛋白、连环蛋白和腺瘤性息肉病蛋白：细胞骨架复合物与信号通路之间的相互作用

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.

作者信息

Barth A I, Näthke I S, Nelson W J

机构信息

Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, CA 94305-5426, USA.

出版信息

Curr Opin Cell Biol. 1997 Oct;9(5):683-90. doi: 10.1016/s0955-0674(97)80122-6.

DOI:10.1016/s0955-0674(97)80122-6

PMID:9330872

Abstract

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

摘要

钙黏着蛋白在组织分化过程中的细胞间黏附中发挥重要作用。钙黏着蛋白通过连环蛋白（β-连环蛋白/犰狳蛋白、桥粒斑珠蛋白和α-连环蛋白）与肌动蛋白细胞骨架相连。最近的研究结果表明，β-连环蛋白还与另一种包含腺瘤性息肉病蛋白和微管的细胞骨架复合体结合，并与包括酪氨酸激酶、磷酸酶以及Wnt/无翅蛋白在内的多种信号通路相互作用。这些细胞骨架复合体与信号通路之间的相互作用可能会调节形态发生。