Giancotti F G
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, Cornell University, New York, NY 10021, USA.
Curr Opin Cell Biol. 1997 Oct;9(5):691-700. doi: 10.1016/s0955-0674(97)80123-8.
Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors.
整合素介导的与细胞外基质的黏附在调节细胞存活和增殖中起重要作用。现在越来越多的证据表明，整合素激活共同的以及亚组特异性的信号通路。来自这些黏附受体的信号与源自生长因子和细胞因子受体的信号整合，以组织细胞骨架、刺激丝裂原活化蛋白激酶级联反应并调节立即早期基因表达。整合素的种类和细胞外基质的组成似乎决定了细胞是否会存活、增殖或退出细胞周期并对可溶性因子作出反应而分化。
