Ruhl C M, Gleich L L, Gluckman J L
Department of Otolaryngology--Head and Neck Surgery, University of Cincinnati Medical Center, Ohio 45267-0528, U.S.A.
Laryngoscope. 1997 Oct;107(10):1316-21. doi: 10.1097/00005537-199710000-00005.
Advanced tongue cancer is associated with poor survival despite aggressive therapy. In an attempt at cure, many patients undergo total glossectomy, which significantly affects function and quality of life (QOL). This study was designed to determine the survival rate and QOL of patients who had undergone total glossectomy. A total of 54 patients underwent total glossectomy, with or without total laryngectomy, for advanced tongue cancer from 1970 to 1996. Patient outcomes were assessed for the following: 1. disease-free survival, 2. function, utilizing the Performance Status Scale (PSS), and 3. QOL, using two general cancer questionnaires (FACT-G and EORTC QLQ-C30) and a series of questions specific for head and neck cancer patients. Corrected actuarial survival was 51% and 41% at 3 and 5 years, respectively. Functional assessment using the PSS demonstrated significant deficits in speech and deglutition. QOL questionnaires revealed problems with eating, speaking, socializing, and shoulder function. However, the overall responses demonstrated that these patients have adjusted to their deficits and have a good QOL. It was concluded that total glossectomy, with or without total laryngectomy, can result in meaningful survival and an adequate QOL can be achieved in selected patients.
尽管采取了积极的治疗措施，晚期舌癌患者的生存率仍然较低。为了治愈疾病，许多患者接受了全舌切除术，这对功能和生活质量（QOL）有显著影响。本研究旨在确定接受全舌切除术患者的生存率和生活质量。1970年至1996年间，共有54例晚期舌癌患者接受了全舌切除术，部分患者还接受了全喉切除术。对患者的以下指标进行了评估：1. 无病生存率；2. 功能，采用体能状态量表（PSS）进行评估；3. 生活质量，使用两份通用癌症问卷（FACT-G和EORTC QLQ-C30）以及一系列针对头颈癌患者的特定问题进行评估。3年和5年的校正精算生存率分别为51%和41%。使用PSS进行的功能评估显示，患者在言语和吞咽方面存在显著缺陷。生活质量问卷显示，患者在进食、说话、社交和肩部功能方面存在问题。然而，总体反馈表明，这些患者已经适应了自身的缺陷，生活质量良好。研究得出结论，无论是否进行全喉切除术，全舌切除术都能带来有意义的生存，并且部分患者能够获得足够的生活质量。
