铜绿假单胞菌耐氟喹诺酮临床分离株中gyrA和parC基因的突变
Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.
作者信息
Nakano M, Deguchi T, Kawamura T, Yasuda M, Kimura M, Okano Y, Kawada Y
机构信息
Department of Urology, Gifu University School of Medicine, Japan.
出版信息
Antimicrob Agents Chemother. 1997 Oct;41(10):2289-91. doi: 10.1128/AAC.41.10.2289.
Abstract
We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.
摘要
我们测定了氟喹诺酮敏感菌株ATCC 27853以及22株铜绿假单胞菌临床分离株的gyrA和parC基因的部分序列。在14株对氟喹诺酮敏感性降低的分离株中，发现GyrA中有单个氨基酸变化，ParC中有或没有变化，而3株对氟喹诺酮耐药性较高的分离株在GyrA中有双氨基酸变化，在ParC中有单个氨基酸变化。
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