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Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.大肠杆菌喹诺酮耐药位点nfxD是编码拓扑异构酶IV一个亚基的parE基因的突变等位基因。
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DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa.铜绿假单胞菌喹诺酮耐药临床分离株中的DNA促旋酶gyrA突变
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铜绿假单胞菌耐氟喹诺酮临床分离株中gyrA和parC基因的突变

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.

作者信息

Nakano M, Deguchi T, Kawamura T, Yasuda M, Kimura M, Okano Y, Kawada Y

机构信息

Department of Urology, Gifu University School of Medicine, Japan.

出版信息

Antimicrob Agents Chemother. 1997 Oct;41(10):2289-91. doi: 10.1128/AAC.41.10.2289.

DOI:10.1128/AAC.41.10.2289
PMID:9333065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164110/
Abstract

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.

摘要

我们测定了氟喹诺酮敏感菌株ATCC 27853以及22株铜绿假单胞菌临床分离株的gyrA和parC基因的部分序列。在14株对氟喹诺酮敏感性降低的分离株中，发现GyrA中有单个氨基酸变化，ParC中有或没有变化，而3株对氟喹诺酮耐药性较高的分离株在GyrA中有双氨基酸变化，在ParC中有单个氨基酸变化。