Maune S, Frese K A, Mrowietz U, Reker U
Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie.
Laryngorhinootologie. 1997 Jun;76(6):368-70. doi: 10.1055/s-2007-997444.
Whereas cochlear impairment after intravenous ingestions of salicylates is well known, reports of cochlear symptoms after topical application are quite rare. The extent of the ototoxic salicylate impact is increased by diabetes, renal insufficiency, and alcoholism.
This study presents a case report of a female patient who suffered a repeated, symmetric, pancochlear, reversible inner ear impairment after two treatments with salicylate containing ointment for psoriasis. The correlation of the salicylate therapy with the observed inner ear lesions is obvious due to the close interval between these incidences and to the audiologic criteria typical for salicylate intoxication.
Audiologic controls should be carried out during extended local application of salicylate containing ointment.
静脉摄入水杨酸盐后导致耳蜗损伤已为人熟知，但局部应用后出现耳蜗症状的报道却极为罕见。糖尿病、肾功能不全和酗酒会加重水杨酸盐耳毒性的影响。
本研究报告了一名女性患者的病例，该患者因使用含水杨酸盐的软膏治疗银屑病两次后，出现了反复、对称、全耳蜗性、可逆性内耳损伤。水杨酸盐治疗与观察到的内耳病变之间的相关性很明显，因为这些事件之间的时间间隔很近，且符合水杨酸盐中毒典型的听力学标准。
在长期局部应用含水杨酸盐的软膏时，应进行听力学监测。
