Jongevos S F, Prens E P, Wolterbeek J H, Habets J M
Afd. Dermatologie, Ziekenhuis Walcheren, Vlissingen.
Ned Tijdschr Geneeskd. 1997 Oct 25;141(43):2075-9.
A 36-year-old woman, hospitalized because of an exacerbation of psoriasis, developed fever, sudden deafness and severe metabolic acidosis after treatment with a 10% salicylic acid containing ointment for four days. The use of salicylic acid on large areas of inflamed skin enhances the risk of transcutaneous resorption and intoxication. High serum concentrations (> 300 mg/l) of salicylic acid deregulate the blood glucose metabolism and cause damage to the inner ear. After timely intervention such symptoms are largely reversible.
一名36岁女性因银屑病加重入院，在使用含10%水杨酸的软膏治疗四天后出现发热、突发性耳聋和严重代谢性酸中毒。在大面积炎症皮肤使用水杨酸会增加经皮吸收和中毒风险。高血清浓度（>300mg/l）的水杨酸会扰乱血糖代谢并损害内耳。经过及时干预，这些症状大多是可逆的。
