Iavorovskiĭ A P, Paustovskiĭ Iu A
Lik Sprava. 1997 Mar-Apr(2):120-3.
The studies made permit stating that such epoxy resins as DE-500 with dose levels of 1/10 and 1/50 DL50, DE-1000 with 1/10, 1/50, 1/100, 1/250 DL50, UP-650, UP-650T with 1/10 DL50 administered into the stomach of pregnant females of nondescript albino rats from the 1st to the 19th day of pregnancy (DL50 being 5338 +/- 1134, 6644 +/- 1114, 9180 +/- 1154, 7717 +/- 586, 6980 +/- 621 mg/kg for the resins DE-500, DE-1000, DE-2000, UP-650, UP-650T respectively) have embryotoxic as well as teratogenic effects. The embryotoxic effect of the above epoxy resins depends on the dose administered and their chemical structure. These same embryotoxic and teratogenic effects a need to be taken into consideration in scientific substantiation/revision of hygienic regulations for polyoxipropilene diepoxides and alicyclic epoxy resins.
所进行的研究表明，将剂量水平为1/10和1/50半数致死剂量（DL50）的DE - 500环氧树脂、剂量水平为1/10、1/50、1/100、1/250 DL50的DE - 1000环氧树脂、剂量水平为1/10 DL50的UP - 650和UP - 650T环氧树脂，在怀孕第1天至第19天给无特定品种的白化大鼠怀孕雌性经口灌胃（DE - 500、DE - 1000、DE - 2000、UP - 650、UP - 650T树脂的DL50分别为5338±1134、6644±1114、9180±1154、7717±586、6980±621毫克/千克），会产生胚胎毒性和致畸作用。上述环氧树脂的胚胎毒性作用取决于给药剂量及其化学结构。在对聚氧丙烯二环氧化物和脂环族环氧树脂的卫生法规进行科学论证/修订时，需要考虑这些相同的胚胎毒性和致畸作用。
