Murata K, Yoshitake Y, Baba N, Suga H, Yamane O
Jpn Heart J. 1976 Mar;17(2):190-5. doi: 10.1536/ihj.17.190.
The Korotkoff sound appearance time (QK intervals) was measured in 224 normal subjects of both sexes between the age of 6 and 79 years. The sex difference was not obvious except for the diastolic values of the intervals (QKd) in the sixth decade. Although the QK intervals remained almost unchanged between the third and the fifth decade, both the systolic (QKs) and the diastolic values were significantly smaller in the young subjects under the age of 20. On the other hand, QKs was significantly decreased and QKd and the difference between the systolic and diastolic values (QKs-d) were significantly increased in the elderly subjects. The short QK interval in the young subjects was considered to be mainly attributable to the short preejection period, while the increased pulse wave velocity was postulated to be the main responsible factor for the shortening of QKd in the elderly subjects. A statistically significant negative correlation was demonstrated between QKd and the heart rate in both sexes, while QKs and QKs-d were not significantly correlated with the heart rate.
对224名年龄在6岁至79岁之间的正常男女受试者测量了柯氏音出现时间（QK间期）。除了第六个十年期的间期舒张压值（QKd）外，性别差异并不明显。虽然QK间期在第三个和第五个十年期之间几乎保持不变，但20岁以下的年轻受试者的收缩压（QKs）和舒张压值均显著较小。另一方面，老年受试者的QKs显著降低，QKd以及收缩压与舒张压值之间的差值（QKs-d）显著增加。年轻受试者QK间期较短主要归因于射血前期较短，而脉搏波速度增加被认为是老年受试者QKd缩短的主要原因。两性的QKd与心率之间均显示出具有统计学意义的负相关，而QKs和QKs-d与心率无显著相关性。
