[The effect of repeated use of cuprophane and polysulfone dialyzers during hemodialysis on the count of natural killer cells in blood].

UNLABELLED

The aim of the study was to compare the effect of hemodialysis with the reused cuprophane and polysulfone dialyzers and bicarbonate dialysis on the count of natural killer cells in the peripheral blood in patients with chronic renal failure during the hour of haemodialysis. The study was performed in 16 patients with chronic renal failure just before haemodialysis (0') as well as 15 and 60 minutes after the beginning of haemodialysis with the first and the fourth use of membranes. The count of natural killer cells (CD3-, CD16+) in the peripheral blood was assessed using the flow cytometry.

CONCLUSIONS

1. The count of natural killer cells (CD3-, CD16+) decreased transiently in the peripheral blood in observed patients during haemodialysis. 2) The use of new cuprophane membrane decreased the count of natural killer cells in peripheral blood during haemodialysis significantly more than the haemodialysis with the use of polysulfone membranes and reused cuprophane membrane. 3) The count of the natural killer cells (CD3-, CD16+) in the peripheral blood in patients with chronic renal failure assessed 15 minutes after the start of haemodialysis could be a marker of dialysis membrane hemocompatibility.