Murphy G G, Glanzman D L
Interdepartmental Graduate Program in Neuroscience, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Science. 1997 Oct 17;278(5337):467-71. doi: 10.1126/science.278.5337.467.
Long-term potentiation (LTP) is considered an important neuronal mechanism of learning and memory. Currently, however, there is no direct experimental link between LTP of an identified synapse and learning. A cellular analog of classical conditioning in Aplysia was used to determine whether this form of invertebrate learning involves N-methyl-D-aspartate (NMDA)-type LTP. The NMDA receptor-antagonist dl-2-amino-5-phosphonovalerate significantly disrupted synaptic enhancement after associative training but did not disrupt synaptic enhancement after nonassociative training. Thus, classical conditioning in Aplysia appears to be mediated, in part, by LTP due to activation of NMDA-related receptors.
长期增强作用（LTP）被认为是学习和记忆的一种重要神经机制。然而，目前在已确定的突触的LTP与学习之间尚无直接的实验联系。利用海兔经典条件反射的细胞类似物来确定这种无脊椎动物学习形式是否涉及N-甲基-D-天冬氨酸（NMDA）型LTP。NMDA受体拮抗剂dl-2-氨基-5-磷酸戊酸在联合训练后显著破坏了突触增强，但在非联合训练后并未破坏突触增强。因此，海兔的经典条件反射似乎部分是由NMDA相关受体激活导致的LTP介导的。
