Lin X Y, Glanzman D L
Department of Physiological Science, University of California, Los Angeles 90024-1568.
Proc Biol Sci. 1994 Feb 22;255(1343):113-8. doi: 10.1098/rspb.1994.0016.
Long-term potentiation (LTP) has been proposed as a cellular mechanism for associative learning in vertebrates. Induction of one type of LTP--observed at synapses in the CA1 region of the mammalian hippocampus--is regulated by the voltage of the postsynaptic cell. To date, a similar form of LTP has not been demonstrated for any invertebrate synapse. We now report that high-frequency stimulation can induce LTP of sensorimotor synapses of the marine mollusc Aplysia in cell culture. Moreover, induction of this form of LTP appears to involve a voltage-dependent postsynaptic mechanism because pairing tetanic stimulation of the presynaptic cell with strong hyperpolarization of the postsynaptic cell blocks the induction of LTP.
长期增强作用（LTP）已被提出作为脊椎动物联想学习的一种细胞机制。一种类型的LTP的诱导——在哺乳动物海马体CA1区的突触中观察到——受突触后细胞电压的调节。迄今为止，尚未在任何无脊椎动物突触中证明存在类似形式的LTP。我们现在报告，高频刺激可在细胞培养中诱导海洋软体动物海兔的感觉运动突触产生LTP。此外，这种形式的LTP的诱导似乎涉及一种电压依赖性突触后机制，因为将突触前细胞的强直刺激与突触后细胞的强超极化配对会阻断LTP的诱导。
