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坐骨神经华勒氏变性过程中ErbB2的激活。

Activation of ErbB2 during wallerian degeneration of sciatic nerve.

作者信息

Kwon Y K, Bhattacharyya A, Alberta J A, Giannobile W V, Cheon K, Stiles C D, Pomeroy S L

机构信息

Department of Biology, College of Arts and Sciences, KyungHee University, Seoul, 130-701 Korea.

出版信息

J Neurosci. 1997 Nov 1;17(21):8293-9. doi: 10.1523/JNEUROSCI.17-21-08293.1997.

DOI:10.1523/JNEUROSCI.17-21-08293.1997
PMID:9334404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6573732/
Abstract

We used anti-phosphopeptide-immunodetecting antibodies as immunohistochemical reagents to define the location and activity state of p185(erbB2) during Wallerian degeneration. Nerve damage induces a phosphorylation event at Y1248, a site that couples p185(erbB2) to the Ras-Raf-MAP kinase signal transduction pathway. Phosphorylation of p185(erbB2) occurs within Schwann cells and coincides in time and space with Schwann cell mitotic activity, as measured by bromodeoxyuridine uptake. These visual images of receptor autophosphorylation link activation of p185(erbB2) to the Schwann cell proliferation that accompanies nerve regeneration.

摘要

我们使用抗磷酸化肽免疫检测抗体作为免疫组织化学试剂，来确定沃勒变性过程中p185（erbB2）的位置和活性状态。神经损伤会在Y1248位点诱导磷酸化事件，该位点将p185（erbB2）与Ras-Raf-MAP激酶信号转导途径相连。p185（erbB2）的磷酸化发生在雪旺细胞内，并且在时间和空间上与通过溴脱氧尿苷摄取所测量的雪旺细胞有丝分裂活性一致。这些受体自身磷酸化的可视化图像将p185（erbB2）的激活与伴随神经再生的雪旺细胞增殖联系起来。