Lufi D, Parish-Plass J, Gai E
Oranim, School of Education of the Kibbutz Movement, Child and Family Clinic, Oranim, Kiryat-Tivon, Israel.
Isr J Psychiatry Relat Sci. 1997;34(3):200-9.
Twenty Israeli children diagnosed as having Attention Deficit Hyperactivity Disorder (ADHD) participated in the study. The study used a double-blind, cross-over, placebo-control design, in which each child received a three-week treatment of methylphenidate (MPH), and a three-week treatment with a placebo. Their teachers completed the Conners' Teacher Rating Scale (CTRS) along with ratings of other variables prior to the beginning of the study and during the two treatment periods. The subjects were tested on a specially designed battery of both cognitive and personality tests at the end of each treatment period. The results showed significant differences between ratings of children's behavior in pretest and subsequent placebo and MPH treatment periods. Comparison of the MPH and placebo treatment revealed no differences in any of the measures assessing cognitive ability and personality characteristics.
20名被诊断患有注意力缺陷多动障碍（ADHD）的以色列儿童参与了这项研究。该研究采用双盲、交叉、安慰剂对照设计，每个孩子接受为期三周的哌甲酯（MPH）治疗和为期三周的安慰剂治疗。他们的老师在研究开始前以及两个治疗阶段完成了康纳斯教师评定量表（CTRS）以及其他变量的评定。在每个治疗阶段结束时，对受试者进行了专门设计的一系列认知和人格测试。结果显示，儿童行为在预测试与随后的安慰剂和MPH治疗阶段的评定之间存在显著差异。MPH与安慰剂治疗的比较显示，在评估认知能力和人格特征的任何指标上均无差异。
