Oehler U, Jürs M, Klöppel G, Helpap B
Department of Pathology, Hegau-Klinikum, Singen, Germany.
Virchows Arch. 1997 Sep;431(3):215-8. doi: 10.1007/s004280050091.
A 57-year-old male patient presented with a cystic lesion in the tail of the pancreas, which was considered to be a pseudocyst. He was treated by cystojejunostomy but one year later a tumour was found to have invaded the stomach and jejunum. This was an osteoclast-like giant cell tumour containing a small area of typical ductal adenocarcinoma. Immunohistochemical staining revealed that the pleomorphic tumour cells were positive for cytokeratin, epithelial membrane antigen, vimentin and the proliferation marker MIB-1. The osteoclast-like giant cells and some small histiocytic cells stained for leukocyte common antigen and histiocytic markers and were negative for MIB-1. At autopsy, tumour rests were found in the pancreas but there were no metastases. Osteoclast-like giant cell tumours of the pancreas may present as cystic lesions and should be included in the differential diagnosis of pseudocysts.
一名57岁男性患者，胰腺尾部出现一个囊性病变，被认为是假性囊肿。他接受了囊肿空肠吻合术治疗，但一年后发现肿瘤侵犯了胃和空肠。这是一个破骨细胞样巨细胞瘤，其中包含一小片典型的导管腺癌区域。免疫组化染色显示，多形性肿瘤细胞细胞角蛋白、上皮膜抗原、波形蛋白和增殖标志物MIB-1呈阳性。破骨细胞样巨细胞和一些小组织细胞白细胞共同抗原和组织细胞标志物染色阳性，MIB-1染色阴性。尸检时，在胰腺中发现了肿瘤残留，但无转移。胰腺破骨细胞样巨细胞瘤可能表现为囊性病变，应列入假性囊肿的鉴别诊断。
