Abele-Horn M, Peters J, Genzel-Boroviczény O, Wolff C, Zimmermann A, Gottschling W
Max von Pettenkofer-Institut, München, Germany.
Infection. 1997 Sep-Oct;25(5):286-91. doi: 10.1007/BF01720398.
The effects of Ureaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized with U. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls, U. urealyticum colonization was associated with a significantly increased rate of amnionitis (2% vs 35%; p < 0.001), chorioamnionitis (0% vs 10%; p < 0.05), premature rupture of membranes (12% vs 35%; p < 0.001) and preterm delivery (10% vs 41%; p < 0.001). The rate of vertical transmission ranged from 38% in term infants to 95% in very low birth weight infants. U. urealyticum colonization at birth was associated with an increased risk for the development of respiratory distress syndrome (9% vs 51%), intraventricular hemorrhage (1% vs 7%) and bronchopulmonary dysplasia (4% vs 17%) in very low birth weight infants (< 1500 g). It is concluded that maternal U. urealyticum colonization is associated with amnionitis, chorioamnionitis and preterm delivery, and that tracheal colonization with U. urealyticum increases the risk for respiratory and neurological complications in very low birth weight infants.
对即将足月或早产的妇女，前瞻性研究了解脲脲原体定植对妊娠及新生儿结局的影响。170名单独定植解脲脲原体作为唯一致病微生物的妇女和83名培养阴性的妇女被纳入研究。与对照组相比，解脲脲原体定植与羊膜炎发生率显著增加相关（2%对35%；p<0.001）、绒毛膜羊膜炎（0%对10%；p<0.05）、胎膜早破（12%对35%；p<0.001）及早产（10%对41%；p<0.001）。垂直传播率在足月儿中为38%，在极低出生体重儿中为95%。出生时解脲脲原体定植与极低出生体重儿（<1500g）发生呼吸窘迫综合征（9%对51%）、脑室内出血（1%对7%）及支气管肺发育不良（4%对17%）的风险增加相关。结论是母亲解脲脲原体定植与羊膜炎、绒毛膜羊膜炎及早产相关，且极低出生体重儿气管定植解脲脲原体增加了呼吸和神经并发症的风险。
