Wang H P, Wang H C, Huang Y J
Department of Environment Engineering, Cheng Kung University, Tainan, Taiwan.
Sci Total Environ. 1997 Oct 1;204(3):283-7. doi: 10.1016/s0048-9697(97)00180-0.
Structural changes associated with lung cancer and tuberculous cells in pleural fluid were studied by microscopic FTIR spectroscopy. Infrared spectra demonstrate significant spectral differences between normal, lung cancer and tuberculous cells. The ratio of the peak intensities of the 1030 and 1080 cm-1 bands (originated mainly in glycogen and phosphodiester groups of nucleic acids) differs greatly between normal and lung cancer samples. Such findings prompt the consideration that recording infrared spectra from lung cancer and tuberculous cells may be of diagnostic value. Since measurements of IR spectra of lung cancer cells in the pleural fluid can be a very rapid inexpensive process, our finding warrant exploration of this possibility in the investigation of the mechanism whereby the environmental pollution related cancers develop.
通过显微傅里叶变换红外光谱法研究了与肺癌和结核细胞相关的胸腔积液结构变化。红外光谱显示正常细胞、肺癌细胞和结核细胞之间存在显著的光谱差异。正常样本与肺癌样本中1030和1080 cm-1波段（主要源于核酸的糖原和磷酸二酯基团）的峰强度之比差异很大。这些发现促使人们考虑记录肺癌和结核细胞的红外光谱可能具有诊断价值。由于测量胸腔积液中肺癌细胞的红外光谱是一个非常快速且廉价的过程，我们的发现值得在研究与环境污染相关癌症的发生机制中探索这种可能性。
