Sheikh-Hamad D, Timmins K, Jalali Z
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
J Am Soc Nephrol. 1997 Oct;8(10):1640-4. doi: 10.1681/ASN.V8101640.
Cisplatin administration is frequently associated with renal insufficiency and tubular dysfunction. In this article, a case of massive cisplatin overdose as a result of an accidental substitution for carboplatin is reported. The patient developed oliguric renal failure, hepatotoxicity, ototoxicity, peripheral neuropathy, blindness, and severe myelosuppression. A therapeutic trial with N-acetylcysteine to reverse renal toxicity was attempted. This article reviews the literature on cisplatin nephrotoxicity, with an emphasis on possible mechanisms involved, and suggests therapy for its modification.
