Robinson G N, van Heerden J A, Payne W S, Taylor W F, Gaffey T A
Mayo Clin Proc. 1976 Jul;51(7):433-42.
To study the effectiveness of a trend at the Mayo Clinic toward modifying the standard radical mastectomy, the 5-year survival of 873 women treated surgically for breast cancer from 1965 through 1968 was evaluated. The observed survival of 534 patients treated by the standard radical mastectomy was 85% when nodes were negative and 56% when nodes were positive. For 339 patients treated by the modified radical mastectomy, the observed survival was 80% and 48% when axillary nodes were negative and positive, respectively. In order to accomplish a more significant analysis of cancer risk and results of the two operative procedures, a relatively homogeneous group of 541 patients was established from the total group. In this homogeneous group, the observed survival of 336 patients treated by the standard radical mastectomy was 86% when nodes were negative and 66% when nodes were positive. For 205 patients treated by the modified radical mastectomy, the observed survival was 84% and 66% when axillary nodes were negative and positive, respectively. When patients were further analyzed and compared according to the extent of axillary-node involvement, age at the time of treatment, grade, size, location, and histopathologic type of tumor, and the use of postoperative irradiation, survival was essentially the same, irrespective of the type of mastectomy performed.
为研究梅奥诊所改变标准根治性乳房切除术这一趋势的有效性，对1965年至1968年接受乳腺癌手术治疗的873名女性的5年生存率进行了评估。接受标准根治性乳房切除术的534例患者，淋巴结阴性时观察到的生存率为85%，淋巴结阳性时为56%。接受改良根治性乳房切除术的339例患者，腋窝淋巴结阴性和阳性时观察到的生存率分别为80%和48%。为了对癌症风险和两种手术方法的结果进行更有意义的分析，从总体中选出了541例相对同质的患者。在这个同质组中，接受标准根治性乳房切除术的336例患者，淋巴结阴性时观察到的生存率为86%，淋巴结阳性时为66%。接受改良根治性乳房切除术的205例患者，腋窝淋巴结阴性和阳性时观察到的生存率分别为84%和66%。当根据腋窝淋巴结受累程度、治疗时的年龄、分级、大小、位置、肿瘤的组织病理学类型以及术后放疗的使用情况对患者进行进一步分析和比较时，无论进行何种类型的乳房切除术，生存率基本相同。
