Baker R R, Montague A C, Childs J N
Ann Surg. 1979 May;189(5):553-9. doi: 10.1097/00000658-197905000-00003.
This study compares the results of modified radical mastectomy (144 cases) to radical mastectomy (188 cases) in the treatment of operable breast cancer. Two hundred five patients had Stage I breast cancer, 60 had Stage II disease and 67 had Stage III disease (TNM System). There was no statistically significant difference in five year survival when the results of a radical mastectomy were compared to a modified radical mastectomy at any stage of disease. There was no statistically significant difference in the incidence of local recurrence in patients with Stage I and Stage II disease when the results of a radical mastectomy were compared to modified radical mastectomy. Those patients with Stage III disease who were treated by a modified radical mastectomy had a statistically significant higher incidence of local recurrence (chest wall and axilla) in comparison to patients treated by radical mastectomy. We have concluded that a modified radical mastectomy is the treatment of choice in patients with Stage I and Stage II diseases. In patients with Stage III disease, a radical mastectomy provides a better chance of local control of the disease but offers no increased chance of survival.
本研究比较了改良根治性乳房切除术（144例）与根治性乳房切除术（188例）治疗可手术乳腺癌的结果。205例患者为I期乳腺癌，60例为II期疾病，67例为III期疾病（TNM系统）。在疾病的任何阶段，将根治性乳房切除术的结果与改良根治性乳房切除术的结果进行比较时，五年生存率没有统计学上的显著差异。将根治性乳房切除术的结果与改良根治性乳房切除术的结果进行比较时，I期和II期疾病患者的局部复发率没有统计学上的显著差异。与接受根治性乳房切除术的患者相比，接受改良根治性乳房切除术治疗的III期疾病患者局部复发（胸壁和腋窝）的发生率在统计学上显著更高。我们得出结论，改良根治性乳房切除术是I期和II期疾病患者的首选治疗方法。对于III期疾病患者，根治性乳房切除术可提供更好的局部疾病控制机会，但生存率并无提高。
