Eklund C, Hiltunen A J, Melin L, Borg S
Department of Clinical Psychology, University of Uppsala, Sweden.
Subst Use Misuse. 1997 Sep;32(11):1599-618. doi: 10.3109/10826089709055882.
Psychological and physiological withdrawal symptoms and some positive factors were studied in 10 methadone maintenance treatment patients during methadone dose reduction. The subjective ratings were made during a period of 10 days around each reduction occasion, 3 days before dose reduction and 7 days after (i.e., within the periods). To permit comparisons of the subjects' ratings between earlier and later stages of the dose reduction process, a division has been made between the first half and the second half of the total reduction occasions (i.e., between the periods). Three of the patients completed the dose reduction, while the others interrupted their withdrawal attempts. The results show that the aggregate psychological symptoms were rated low, but that, as expected, they increased significantly from the first to the second half of the dose reduction. A significant increase of the psychological symptoms also occurred from the days before each reduction to the days after. The aggregate physiological symptoms were rated very low. A significant increase in rated withdrawal intensity is found within the reduction occasions. There were no significant changes with regard to the aggregate positive factors, either within or between the reduction occasions.
对10名美沙酮维持治疗患者在美沙酮剂量减少期间的心理和生理戒断症状以及一些积极因素进行了研究。主观评分在每次减量前后各10天内进行，即减量前3天和减量后7天（即在此期间内）。为了比较受试者在剂量减少过程早期和后期的评分，在总减量次数的前半段和后半段（即在此期间之间）进行了划分。3名患者完成了剂量减少，而其他患者中断了戒断尝试。结果表明，总的心理症状评分较低，但正如预期的那样，从剂量减少的前半段到后半段显著增加。每次减量前几天到减量后几天，心理症状也显著增加。总的生理症状评分非常低。在减量期间发现戒断强度评分显著增加。在减量期间内或减量期间之间，总的积极因素没有显著变化。
