Hargrave M, Wright E, Kun J, Emery J, Cooper L, Koopman P
Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia.
Dev Dyn. 1997 Oct;210(2):79-86. doi: 10.1002/(SICI)1097-0177(199710)210:2<79::AID-AJA1>3.0.CO;2-6.
Sry, the mammalian Y-linked testis determining gene, is a member of a family of genes known as Sox genes, which encode transcription factors related by a DNA-binding motif termed the HMG box. Sox genes are known to have diverse roles in vertebrate differentiation and development. We report here the cloning and characterisation of one of these genes, Sox11, in mice. In addition to an N-terminal HMG box domain, the deduced SOX11 protein contains a number of highly conserved C-terminal motifs, which may function in transcriptional regulation. Expression of Sox11 in mouse embryos was prominent in the periventricular cells of the central nervous system, suggesting a role in neuronal maturation. Expression was also observed in a wide range of tissues involved in epithelial-mesenchymal interactions, suggesting an additional role in tissue modelling during development.
Sry是哺乳动物Y染色体上的睾丸决定基因，是Sox基因家族的成员之一，该家族基因编码与一种名为HMG盒的DNA结合基序相关的转录因子。已知Sox基因在脊椎动物的分化和发育中具有多种作用。我们在此报告小鼠中这些基因之一Sox11的克隆和特性。除了N端HMG盒结构域外，推导的SOX11蛋白还包含许多高度保守的C端基序，这些基序可能在转录调控中发挥作用。Sox11在小鼠胚胎中的表达在中枢神经系统的脑室周围细胞中很突出，表明其在神经元成熟中起作用。在涉及上皮-间充质相互作用的广泛组织中也观察到了表达，表明其在发育过程中的组织建模中还有额外作用。
