Seok Jaekwon, Gil Minchan, Dayem Ahmed Abdal, Saha Subbroto Kumar, Cho Ssang-Goo
Department of Stem Cell and Regenerative Biotechnology, Incurable Disease Animal Model & Stem Cell Institute (IDASI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
J Pers Med. 2021 Aug 23;11(8):823. doi: 10.3390/jpm11080823.
The Sry-related HMG BOX (SOX) gene family encodes transcription factors containing highly conserved high-mobility group domains that bind to the minor groove in DNA. Although some SOX genes are known to be associated with tumorigenesis and cancer progression, their expression and prognostic value have not been systematically studied. We performed multi-omic analysis to investigate the expression of SOX genes in human cancers. Expression and phylogenetic tree analyses of the SOX gene family revealed that the expression of three closely related SOX members, , , and , was increased in multiple cancers. Expression, mutation, and alteration of the three SOX members were evaluated using the Oncomine and cBioPortal databases, and the correlation between these genes and clinical outcomes in various cancers was examined using the Kaplan-Meier, PrognoScan, and R2 database analyses. The genes commonly correlated with the three SOX members were categorized in key pathways related to the cell cycle, mitosis, immune system, and cancer progression in liver cancer and sarcoma. Additionally, functional protein partners with three SOX proteins and their probable signaling pathways were explored using the STRING database. This study suggests the prognostic value of the expression of three SOX genes and their associated pathways in various human cancers.
与性别决定区Y相关的高迁移率族盒（SOX）基因家族编码含有高度保守的高迁移率族结构域的转录因子，这些结构域与DNA小沟结合。尽管已知一些SOX基因与肿瘤发生和癌症进展相关，但其表达及预后价值尚未得到系统研究。我们进行了多组学分析以研究SOX基因在人类癌症中的表达。SOX基因家族的表达及系统发育树分析显示，三个密切相关的SOX成员，即 、 和 ，在多种癌症中的表达均增加。使用Oncomine和cBioPortal数据库评估了这三个SOX成员的表达、突变和改变情况，并使用Kaplan-Meier、PrognoScan和R2数据库分析检查了这些基因与各种癌症临床结局之间的相关性。与这三个SOX成员共同相关的基因被归类于与细胞周期、有丝分裂、免疫系统以及肝癌和肉瘤中的癌症进展相关的关键途径中。此外，使用STRING数据库探索了与三种SOX蛋白相关的功能性蛋白伴侣及其可能的信号通路。本研究提示了三种SOX基因的表达及其相关途径在各种人类癌症中的预后价值。
