重组人肿瘤坏死因子-α对大鼠莫里斯肝癌肺转移的保护作用
Protective effect of human recombinant tumour necrosis factor-alpha against lung metastases of the Morris hepatoma in rats.
作者信息
Terlikowski S, Nowak H F, Sulkowska M, Sulkowski S
机构信息
Department of Gynecology and Septic Obstetrics, Medical School of Białystok.
出版信息
Rocz Akad Med Bialymst. 1997;42 Suppl 1:346-53.
The effect of intratumour (i.t.) administration of human recombinant tumour necrosis factor-alpha (hrecTNF-alpha) on Morris 5123 hepatoma spontaneous lung metastases was studied. Tumour was implanted in the skeletal muscles of the right hind limb of Buffalo rats. Two weeks after the implantation treatment with cytokine started. The cytokine was injected i.t. in a single dose of 10 micrograms in 4- and 8-day cycles. In control animals PBS was administered, respectively. Then all rats were necropsied and the extent of lung metastases was determined. Data were expressed as volume of lung metastases. In this study we observed significant antimetastatic effects of hrecTNF-alpha (p < 0.05) determined by reduced volume of lung metastases in treated animals.
研究了瘤内（i.t.）注射人重组肿瘤坏死因子-α（hrecTNF-α）对Morris 5123肝癌自发性肺转移的影响。将肿瘤植入水牛大鼠右后肢的骨骼肌中。植入后两周开始用细胞因子进行治疗。细胞因子以10微克的单剂量在4天和8天的周期内进行瘤内注射。在对照动物中分别给予磷酸盐缓冲盐水（PBS）。然后对所有大鼠进行尸检并确定肺转移的程度。数据以肺转移灶的体积表示。在本研究中，我们观察到hrecTNF-α具有显著的抗转移作用（p < 0.05），这是通过治疗动物肺转移灶体积的减少来确定的。
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