正常大小视盘中的大杯状凹陷：脑室周围白质软化症患儿视神经发育不全的一种变体
Large cups in normal-sized optic discs: a variant of optic nerve hypoplasia in children with periventricular leukomalacia.
作者信息
Jacobson L, Hellström A, Flodmark O
机构信息
Department of Ophthalmology, Karolinska Institute, Huddinge University Hospital, Sweden.
出版信息
Arch Ophthalmol. 1997 Oct;115(10):1263-9. doi: 10.1001/archopht.1997.01100160433007.
OBJECTIVE
To evaluate optic disc morphologic features in children with periventricular leukomalacia (PVL).
PATIENTS AND METHODS
Seventeen children with PVL (patient group) were compared with 17 sex- and age-matched, full-term healthy control children (control group). Clinical ophthalmological examination and digital image analysis of fundus photographs were performed in all children. In children with PVL, cerebral imaging was performed.
RESULTS
Children with PVL had larger optic disc cupping (P<.02) than did control children. A large proportion of the children with PVL had strabismus, nystagmus, and restricted visual fields.
CONCLUSION
Our study indicates that optic nerve hypoplasia in children with PVL is often associated with a normal-sized optic disc with a large cup. This unusual form of optic nerve hypoplasia most likely results from transsynaptic degeneration of optic axons caused by the primary bilateral lesion in the optic radiation.
目的
评估脑室周围白质软化症（PVL）患儿的视盘形态学特征。
患者与方法
将17例PVL患儿（患者组）与17例性别和年龄匹配的足月健康对照儿童（对照组）进行比较。对所有儿童进行临床眼科检查和眼底照片的数字图像分析。对PVL患儿进行脑部成像检查。
结果
PVL患儿的视盘杯状凹陷比对照儿童更大（P<0.02）。很大一部分PVL患儿有斜视、眼球震颤和视野受限。
结论
我们的研究表明，PVL患儿的视神经发育不全常与视盘大小正常但杯状凹陷大有关。这种不寻常的视神经发育不全形式很可能是由视辐射原发性双侧病变导致的视轴突跨突触变性所致。
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