Fresno Contreras M J, Jiménez Soriano M M, Sellés Flores E
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid.
Ann Pharm Fr. 1997;55(4):174-80.
The future EU prohibition (Directive 86/609/CEE) of using experimentation animals has induced the implementation of non-invasive techniques which are to substitute the present methods. Two non-invasive techniques are used to determine the cosmetological effectiveness of two emulsions formulated on a modern excipient NEO-PCL Base. Furthermore, the incorporation of multiflower honey is analyzed, being carried out the appropriate essays in order to obtain its tipification from a galenic and rheological point of view. After the formulation adjustment, O/W emulsioned systems, eudermic pH, and the rheological parameters to its application on the skin are obtained. Out of the effectiveness study, a high moisturization/emolliency degree is deduced. On the other hand, we conclude that multiflower honey rises the moisturizing power on this kind of products.
欧盟未来（86/609/CEE号指令）对使用实验动物的禁令促使了非侵入性技术的实施，这些技术旨在替代现有方法。使用两种非侵入性技术来测定以现代辅料新聚己内酯基体制备的两种乳液的美容效果。此外，还分析了多花蜂蜜的添加情况，并进行了适当的试验，以便从药剂学和流变学角度对其进行表征。经过配方调整，获得了水包油乳液体系、皮肤pH值以及其在皮肤上应用的流变学参数。从有效性研究中得出，该乳液具有较高的保湿/润肤程度。另一方面，我们得出结论，多花蜂蜜提高了这类产品的保湿能力。
