Millis K K, Maas W E, Cory D G, Singer S
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Magn Reson Med. 1997 Sep;38(3):399-403. doi: 10.1002/mrm.1910380307.
The recently developed technique of gradient, high-resolution magic-angle spinning NMR (g-hr-MAS-NMR) spectroscopy was applied to the study of ex vivo human lipoma and liposarcoma tissue. Compared with conventional 1H-NMR, the g-hr-MAS method yielded a large improvement in spectral resolution and permitted the detection of metabolite resonance's in a well-differentiated liposarcoma that was not observed in spectra of similar samples obtained using nonspinning NMR methods. These findings suggest that g-hr-MAS-NMR spectroscopy provides a key improvement in spectral quality for ex vivo lipoma and liposarcoma tissue thereby permitting a more precise determination of tissue metabolite composition than conventional nonspinning NMR methods.
最近开发的梯度高分辨率魔角旋转核磁共振（g-hr-MAS-NMR）光谱技术被应用于离体人类脂肪瘤和脂肪肉瘤组织的研究。与传统的1H-NMR相比，g-hr-MAS方法在光谱分辨率上有了很大提高，并能够检测到在使用非旋转NMR方法获得的类似样品光谱中未观察到的高分化脂肪肉瘤中的代谢物共振。这些发现表明，g-hr-MAS-NMR光谱技术为离体脂肪瘤和脂肪肉瘤组织的光谱质量提供了关键改进，从而比传统的非旋转NMR方法能够更精确地确定组织代谢物组成。
