Hassan N H
Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.
J Appl Toxicol. 1997 Sep-Oct;17(5):313-9. doi: 10.1002/(sici)1099-1263(199709)17:5<313::aid-jat444>3.0.co;2-6.
The genotoxic effects of miconazole (MC) were studied in mouse bone-marrow cells and primary spermatocytes at diakinesis metaphase I of meiosis. The ability of miconazole to induce chromosomal aberrations was investigated. Both acute and subacute treatments were tested. Doses were 0.1, 0.5 and 1 mg per animal. Both acute and subacute treatments induced statistically significant dose-dependent chromosomal aberrations. The effect of miconazole on sperm head morphology was also studied in animals treated for five successive days with the three doses. Morphological sperm head abnormalities increased significantly after treatment with miconazole. The increase was dose-dependent. These results suggests that miconazole has a genotoxic effect on mice somatic and germ cells.
研究了咪康唑（MC）对小鼠骨髓细胞以及减数分裂终变期 I 的初级精母细胞的遗传毒性作用。研究了咪康唑诱导染色体畸变的能力。对急性和亚急性处理均进行了测试。剂量为每只动物 0.1、0.5 和 1 毫克。急性和亚急性处理均诱导出具有统计学意义的剂量依赖性染色体畸变。还对用这三种剂量连续处理五天的动物研究了咪康唑对精子头部形态的影响。用咪康唑处理后，精子头部形态异常显著增加。这种增加呈剂量依赖性。这些结果表明，咪康唑对小鼠体细胞和生殖细胞具有遗传毒性作用。
