Tvorogova M G, Rozhkova T A, Lupanov V P, Diakishev A A, Titov V N
Klin Lab Diagn. 1997 Jul(7):19-22.
Total and lipid-bound sialic acids in the blood were measured and lipoprotein metabolism assessed in 219 men and women with primary (n = 129, coronary patients) and secondary (n = 66, patients with type II diabetes) hyperlipoproteinemias and normolipidemia (n = 24, normal subjects). The level of total sialic acids in coronary patients reliably differed from that in normal subjects or diabetics. The level of lipid-bound sialic acids was the same in coronary patients and normal subjects and reliably higher in diabetics. The results do not confirm the hypothesis about the probable diagnostic value of total and lipid-bound sialic acids as markers of coronary disease and coronary atherosclerosis. Measurement of total sialic acids may be one of the tests verifying the disorders of lipoprotein metabolism.
对219名患有原发性（n = 129，冠心病患者）和继发性（n = 66，II型糖尿病患者）高脂血症以及血脂正常者（n = 24，正常受试者）的男性和女性进行了血液中总唾液酸和脂质结合唾液酸的测量，并评估了脂蛋白代谢情况。冠心病患者的总唾液酸水平与正常受试者或糖尿病患者的水平存在显著差异。冠心病患者和正常受试者的脂质结合唾液酸水平相同，而糖尿病患者的脂质结合唾液酸水平显著更高。这些结果并未证实关于总唾液酸和脂质结合唾液酸作为冠心病和冠状动脉粥样硬化标志物可能具有诊断价值的假设。总唾液酸的测量可能是验证脂蛋白代谢紊乱的检测方法之一。
