Gavella M, Lipovac V, Crnek S
Institut za dijabetes, endocrinologiyu i bolesti metabolizma Vuk Vrhovac, Medicinski fakultet Sveucilista u Zagrebu, Yugoslavia.
Acta Diabetol Lat. 1990 Oct-Dec;27(4):357-64. doi: 10.1007/BF02580941.
The total and ganglioside-bound sialic acid content of unfractionated blood lymphocytes obtained from normal-weight healthy subjects (n = 17) and non-insulin-dependent diabetic patients on oral hypoglycemic drugs arbitrarily divided into normal-weight (n = 11), moderately overweight (n = 14) and severely overweight (n = 17) subgroups were examined. In normal-weight diabetics the level of lipid-bound sialic acid (gangliosides) of lymphocytes was found to be reduced (p less than 0.01). A more pronounced decrease (p less than 0.001) was observed for the lymphocyte total sialic acid of normal-weight and moderately overweight diabetics as compared to healthy subjects. In severely overweight non-insulin-dependent diabetics the decrease of total sialic acid was less pronounced compared to that found in healthy subjects. Whether this finding was due to obesity in these patients remains to be clarified.
对体重正常的健康受试者（n = 17）以及服用口服降糖药的非胰岛素依赖型糖尿病患者的全血淋巴细胞中总唾液酸和与神经节苷脂结合的唾液酸含量进行了检测，这些糖尿病患者被任意分为体重正常（n = 11）、中度超重（n = 14）和重度超重（n = 17）亚组。在体重正常的糖尿病患者中，发现淋巴细胞中与脂质结合的唾液酸（神经节苷脂）水平降低（p < 0.01）。与健康受试者相比，体重正常和中度超重的糖尿病患者的淋巴细胞总唾液酸有更明显的下降（p < 0.001）。在重度超重的非胰岛素依赖型糖尿病患者中，总唾液酸的下降与健康受试者相比不太明显。这一发现是否归因于这些患者的肥胖仍有待阐明。
