Gahn G, Ackerman R H, Candia M R
Neurovascular Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Ultraschall Med. 1997 Jun;18(3):101-4. doi: 10.1055/s-2007-1000403.
Ultrasound is widely used in the assessment of neurovascular diseases. In spite of its effectiveness there are considerable limitations such as low flow detection in carotid disease or limited bony windows in transcranial Doppler. One approach to overcome these limitations is the use of ultrasound contrast enhancing agents. The usefulness of ultrasound contrast enhancing agents Levovist, EchoGen and BY 963 in neurovascular applications has been evaluated. Contrast enhanced colourflow Doppler for the diagnosis of carotid disease has been investigated in three small trials and might be effective for improving the diagnostic yield in severe disease. Contrast enhanced transcranial colourflow Doppler has been relatively more widely explored also with promising results. Based on the combined findings out of these preliminary investigational trials, it appears to be reasonable to undertake larger trials for assessment of usefulness of ultrasound contrast agents for a variety of neurovascular applications.
超声广泛应用于神经血管疾病的评估。尽管其具有有效性，但仍存在相当多的局限性，如颈动脉疾病中低血流检测或经颅多普勒中有限的骨窗。克服这些局限性的一种方法是使用超声造影剂。已评估了超声造影剂Levovist、EchoGen和BY 963在神经血管应用中的有用性。在三项小型试验中研究了超声造影剂增强彩色血流多普勒用于诊断颈动脉疾病，其可能对提高严重疾病的诊断率有效。超声造影剂增强经颅彩色血流多普勒也得到了相对更广泛的探索，结果也很有前景。基于这些初步研究试验的综合结果，开展更大规模的试验以评估超声造影剂在各种神经血管应用中的有用性似乎是合理的。
