Hitschold T, Berle P
Frauenklinik Wiesbaden.
Ultraschall Med. 1997 Jun;18(3):134-8. doi: 10.1055/s-2007-1000409.
The diagnostic value and the complication rate of transabdominal chorionic villi and placental sampling was compared with standard amniocenteses. The method ist especially helpful in cases with conspicuous fetal sonographic findings.
The results of 475 biopsies were retrospectively compared with 983 amniocenteses and chorionic villi samplings (CVS).
64% of chorionic villi samplings (CVS) were performed in the first, 30% in the second and 6% in the third trimester. The indications were advanced maternal age (45%) and psychological problems (14%) in the first trimester and conspicuous maternal serum markers (11%) or fetal ultrasound anomalies (12%) in the second and third trimester, respectively. 10 out of 20 aneuploid cytogenetic results were found in fetuses with sonographic anomalies. In 4 cases we found confined placental mosaicism, which was clarified by means of amniocentesis and cordocentesis. We had 8 miscarriages in a total of 475 CVS procedures; 6 in 304 before the 15th week of gestation (1.97%). The natural abortion rate in this gestational age is about 1%, the CVS-related abortion rate therefore is near 1%.
Transabdominal CVS is a low risk method for rapid karyotyping during the entire pregnancy.
比较经腹绒毛取样和胎盘取样与标准羊膜穿刺术的诊断价值及并发症发生率。该方法在胎儿超声检查结果明显的病例中特别有用。
对475例活检结果与983例羊膜穿刺术和绒毛取样（CVS）进行回顾性比较。
64%的绒毛取样（CVS）在孕早期进行，30%在孕中期进行，6%在孕晚期进行。其指征在孕早期为高龄产妇（45%）和心理问题（14%），在孕中期和孕晚期分别为明显的母血清标志物（11%）或胎儿超声异常（12%）。20例非整倍体细胞遗传学结果中有10例在超声异常的胎儿中发现。4例发现局限性胎盘嵌合体，通过羊膜穿刺术和脐血穿刺术得以明确。在总共475例CVS操作中有8例流产；304例在妊娠15周前有6例（1.97%）。该孕周的自然流产率约为1%，因此CVS相关流产率接近1%。
经腹CVS是整个孕期快速进行核型分析的低风险方法。
