Franca I, Poiares-Baptista A, Pais M J, Araújo C, Chorão M, Ricardo J L, Mansinho K
Unidade de Doenças Infecciosas e Parasitárias, Hospital Egas Moniz/Instituto de Higiene e Medicina Tropical, Lisboa.
Acta Med Port. 1997 Jun-Jul;10(6-7):479-84.
Cutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesions. Because of this fact, its diagnosis is rare and frequently accidental. The presence of the virus has also been observed in apparently normal skin, from both a clinical and histological point of view. In this context, skin biopsy and immunohistochemistry are often the first means of diagnosis of systemic CMV infection. In 180 skin biopsies carried out on HIV patients in the Infectious and Parasitic Diseases Unit, typical histopathological findings of CMV infection in a nonspecific skin lesion were observed in only one patient. Although the patient showed no extracutaneous manifestations at this time, she died soon after this diagnosis. Because of this fact, we review the literature and discuss the difficulties and implications of the diagnosis of cutaneous CMV infection in AIDS patients.
皮肤巨细胞病毒（CMV）感染已在多种非特异性皮肤病变中被观察到。鉴于此，其诊断罕见且常常是偶然的。从临床和组织学角度来看，在看似正常的皮肤中也观察到了该病毒的存在。在此背景下，皮肤活检和免疫组织化学常常是诊断系统性CMV感染的首要手段。在传染病和寄生虫病科对HIV患者进行的180例皮肤活检中，仅在一名患者的非特异性皮肤病变中观察到了CMV感染的典型组织病理学表现。尽管该患者此时没有皮肤外表现，但在诊断后不久便去世了。鉴于此，我们回顾了文献并讨论了艾滋病患者皮肤CMV感染诊断的困难及意义。
