Jones A M, Kennedy N, Hanson J, Fenton G W
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, UK.
Nucl Med Commun. 1997 Jul;18(7):662-7. doi: 10.1097/00006231-199707000-00011.
Twenty-six people with Down's syndrome (DS) were investigated using 99Tc(m)-hexamethylpropylene amine oxime (99Tc(m)-HMPAO) and single photon emission tomography (SPET). Dementia was diagnosed using a structured carer interview giving a deterioration score and by studying the case notes. Five subjects were clinically demented, 7 showed mild deterioration and 14 no deterioration. Increased deterioration correlated with advancing age (correlation coefficient 0.5425; P<0.02), but there was no significant difference between older (>40 years) and younger (<40 years) patients. Only one of the subjects with dementia had a regional cerebral blood flow (rCBF) abnormality that was of the dementia of Alzheimer type. Three subjects with mild deterioration and three with no deterioration had abnormal SPET scans. There was no association between the SPET abnormality and clinical dementia or with evidence of deterioration.
对26名唐氏综合征（DS）患者使用锝-99m（99Tc(m)）-六甲基丙烯胺肟（99Tc(m)-HMPAO）和单光子发射断层扫描（SPET）进行了研究。通过结构化的护理人员访谈给出恶化评分并研究病历记录来诊断痴呆症。5名受试者临床诊断为痴呆，7名显示轻度恶化，14名未出现恶化。恶化加剧与年龄增长相关（相关系数0.5425；P<0.02），但年龄较大（>40岁）和年龄较小（<40岁）的患者之间无显著差异。只有1名痴呆受试者出现了阿尔茨海默型痴呆的局部脑血流（rCBF）异常。3名轻度恶化受试者和3名未出现恶化受试者的SPET扫描异常。SPET异常与临床痴呆或恶化证据之间无关联。
