Vinekar A S, Andrade C, Sriprada V T, George J, Joseph T, Chandra J S
Department of Pharmacology, St. John's Medical College, Bangalore, India.
J ECT. 1998 Jun;14(2):83-8.
Earlier research indicated the efficacy of a complex herbal formulation in the attenuation of electroconvulsive shock (ECS)-induced amnestic deficits in rats; this study sought to ascertain whether a simplified herbal formulation (Memorin; Phyto-Pharma, India) also was effective. Rats pretreated for a fortnight with Memorin (200 mg/kg/day) or vehicle were exposed to a passive-avoidance learning paradigm in a shuttle box. The next day, the rats were administered two true or sham ECSs, 5 h apart; recall of the pre-ECS learning was reassessed on the following day. ECS was found to produce significant retrograde amnesia (p < 0.002). Memorin attenuated the ECS-induced amnesia (p = 0.00003) without influencing the ECS seizure duration. The clinical implications of these findings are discussed.
早期研究表明，一种复方草药制剂可减轻大鼠电惊厥休克（ECS）诱导的记忆缺失；本研究旨在确定一种简化的草药制剂（Memorin；印度植物制药公司）是否也有效。用Memorin（200毫克/千克/天）或赋形剂预处理两周的大鼠在穿梭箱中接受被动回避学习范式。第二天，给大鼠间隔5小时进行两次真实或假的ECS；在接下来的一天重新评估ECS前学习的记忆情况。发现ECS会产生显著的逆行性遗忘（p < 0.002）。Memorin减轻了ECS诱导的遗忘（p = 0.00003），而不影响ECS发作持续时间。讨论了这些发现的临床意义。
