Folkard M, Vojnovic B, Prise K M, Bowey A G, Locke R J, Schettino G, Michael B D
Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK.
Int J Radiat Biol. 1997 Oct;72(4):375-85. doi: 10.1080/095530097143158.
Charged-particle microbeams provide a unique opportunity to control precisely, the dose to individual cells and the localization of dose within the cell. The Gray Laboratory is now routinely operating a charged-particle microbeam capable of delivering targeted and counted particles to individual cells, at a dose-rate sufficient to permit a number of single-cell assays of radiation damage to be implemented. By this means, it is possible to study a number of important radiobiological processes in ways that cannot be achieved using conventional methods. This report describes the rationale, development and current capabilities of the Gray Laboratory microbeam.
带电粒子微束提供了一个独特的机会，可以精确控制单个细胞的剂量以及剂量在细胞内的定位。格雷实验室目前正在常规操作一台带电粒子微束，它能够以足以进行多项辐射损伤单细胞检测的剂量率，将靶向且可计数的粒子输送到单个细胞。通过这种方式，可以用传统方法无法实现的方式研究许多重要的放射生物学过程。本报告描述了格雷实验室微束的原理、发展情况和当前性能。
