Dubovsky J, Meyer R D
Nephron. 1976;17(1):20-7. doi: 10.1159/000180707.
An abnormal peak of hydroxyproline polypeptides has been observed when the polypeptide fraction from the urines of patients with advanced chronic uremia was subjected to gel chromatography. This abnormality was apparently related to the degree of uremia and to the presence of uremic osteodystrophy. The abnormal peak was not observed in patients with high turnover bone disease without renal insufficiency and in patients with nephrotic syndrome and normal glomerular filtration rate.
当对晚期慢性尿毒症患者尿液中的多肽部分进行凝胶色谱分析时，观察到羟脯氨酸多肽出现异常峰。这种异常显然与尿毒症的程度以及尿毒症性骨营养不良的存在有关。在没有肾功能不全的高转换型骨病患者以及肾病综合征且肾小球滤过率正常的患者中未观察到异常峰。
