McConkey D J, Orrenius S
Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Biochem Biophys Res Commun. 1997 Oct 20;239(2):357-66. doi: 10.1006/bbrc.1997.7409.
Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca2+ in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca2+ in apoptotic cells. This review will summarize the role of Ca2+ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis.
细胞凋亡（程序性细胞死亡）因其在多种生理和病理过程中的作用而受到广泛关注，然而细胞凋亡究竟是如何受到外部和内部信号调节的仍不清楚。我们实验室和其他研究机构的工作表明细胞内钙离子的变化与细胞凋亡有关，并且最近的研究已经明确了凋亡细胞中钙离子作用的特定生化过程。本综述将在已知的细胞凋亡效应机制核心成分的背景下，总结钙离子在细胞凋亡中的作用。
