Seligson D, Mehta S, Mishra A K, FitzGerald T J, Castleman D W, James A H, Voor M J, Been J, Nawab A
Department of Orthopaedic Surgery, University of Louisville, KY 40292, USA.
Clin Orthop Relat Res. 1997 Oct(343):213-23.
A sheep study was performed to compare the in vivo performance of bone plates of 316L stainless steel and a new titanium alloy, titanium + 13% niobium + 13% zirconium (Ti-13Nb-13Zr), which had been subjected to a diffusion hardening treatment to produce a blue, wear resistant surface. Bone plates and screws of stainless steel and diffusion hardened Ti-13Nb-13Zr were implanted in adult sheep, in one group (with unosteotomized femurs) for 16 weeks, and in the other (with osteotomized femurs) for 8 weeks. At harvest, the diffusion hardened Ti-13Nb-13Zr devices had superior fixation strength, with greater screw torque out strength and fewer loose screws. In the osteotomized animals, the femurs with diffusion hardened Ti-13Nb-13Zr plates had higher torsional strength after removal of the implants; however, the difference was not statistically significant. In the unosteotomized animals, the torsional strength of the femurs was identical for both materials. There was a slightly reduced incidence of infection (bacterial adhesion) for the sheep with diffusion hardened Ti-13Nb-13Zr implants. In a parallel in vitro study, the magnetic resonance imaging compatibility of Ti-13Nb-13Zr was significantly superior to that of stainless steel. This indicates that diffusion hardened Ti-13Nb-13Zr may be an attractive alternative material for osteosynthesis.
进行了一项绵羊研究，以比较316L不锈钢骨板和一种新型钛合金（钛+13%铌+13%锆，Ti-13Nb-13Zr）的体内性能，该新型钛合金经过扩散硬化处理以产生蓝色耐磨表面。将不锈钢和扩散硬化的Ti-13Nb-13Zr制成的骨板和螺钉植入成年绵羊体内，一组（股骨未截骨）植入16周，另一组（股骨截骨）植入8周。在取出植入物时，扩散硬化的Ti-13Nb-13Zr装置具有更好的固定强度，拧出螺钉所需的扭矩更大，且松动的螺钉更少。在截骨动物中，植入扩散硬化的Ti-13Nb-13Zr骨板的股骨在取出植入物后具有更高的抗扭强度；然而，差异无统计学意义。在未截骨的动物中，两种材料的股骨抗扭强度相同。植入扩散硬化的Ti-13Nb-13Zr的绵羊感染（细菌粘附）发生率略有降低。在一项平行的体外研究中，Ti-13Nb-13Zr的磁共振成像兼容性明显优于不锈钢。这表明扩散硬化的Ti-13Nb-13Zr可能是一种有吸引力的骨合成替代材料。
