Walter M S, Frank M J, Sunding M F, Gómez-Florit M, Monjo M, Bucko M M, Pamula E, Lyngstadaas S P, Haugen H J
Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, PO Box 1109 Blindern, 0317, Oslo, Norway.
J Mater Sci Mater Med. 2013 Dec;24(12):2761-73. doi: 10.1007/s10856-013-5020-4. Epub 2013 Aug 3.
In the quest for improved bone growth and attachment around dental implants, chemical surface modifications are one possibility for future developments. The biological properties of titanium based materials can be further enhanced with methods like anodic polarization to produce an active rather than a passive titanium oxide surface. Here we investigate the formation of hydroxide groups on sand blasted and acid etched titanium and titanium-zirconium alloy surfaces after anodic polarization in an alkaline solution. X-ray photoelectron spectroscopy shows that the activated surfaces had increased reactivity. Furthermore the activated surfaces show up to threefold increase in OH(-) concentration in comparison to the original surface. The surface parameters Sa, Sku, Sdr and Ssk were more closely correlated to time and current density for titanium than for titanium-zirconium. Studies with MC3T3-E1 osteoblastic cells showed that OH(-) activated surfaces increased mRNA levels of osteocalcin and collagen-I.
在寻求改善牙种植体周围的骨生长和附着方面，化学表面改性是未来发展的一种可能性。通过阳极极化等方法可以进一步增强钛基材料的生物学性能，从而产生活性而非钝化的二氧化钛表面。在此，我们研究了在碱性溶液中进行阳极极化后，喷砂和酸蚀钛及钛锆合金表面上羟基的形成情况。X射线光电子能谱表明，活化后的表面具有更高的反应活性。此外，与原始表面相比，活化后的表面OH(-)浓度增加了两倍。对于钛而言，表面参数Sa、Sku、Sdr和Ssk与时间和电流密度的相关性比钛锆合金更为紧密。对MC3T3-E1成骨细胞的研究表明，OH(-)活化后的表面增加了骨钙素和I型胶原蛋白的mRNA水平。
